Disposition of tissue factor pathway inhibitor during cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
Biology of tissue factor pathway inhibitor.
Recent studies of the anticoagulant activities of the tissue factor (TF) pathway inhibitor (TFPI) isoforms, TFPIα and TFPIβ, have provided new insight into the biochemical and physiological mechanisms that underlie bleeding and clotting disorders. TFPIα and TFPIβ have tissue-specific expression patterns and anticoagulant activities. An alternative splicing event in the 5' untranslated region al...
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For cardiopulmonary bypass during open-heart surgery we use a bubble oxygenator and a technique of haemodilution and moderate hypothermia. During the course of routine perfusion we have observed arterial desaturation in a number of patients and in five patients the desaturation was marked (SaO2<85%)'. The low arterial oxygen saturations occurred mainly in the rewarming period. This report is of...
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The effect of cardiopulmonary bypass (CPB) on the disposition of vancomycin (15 mg/kg) and of netilmicin (3 mg/kg) was studied in 10 adults. The concentration-time profile of the drug in serum and renal clearance were characterized pre-CPB, during CPB, and post-CPB. Vancomycin and netilmicin exhibited initial decreases in mean concentrations in serum of 4.0 mg/liter (16.8%) and 2.2 mg/liter (29...
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The pharmacokinetic parameters of intravenous ciprofloxacin were examined in five adult male patients on three separate occasions of open heart surgery: the 24 h before cardiopulmonary bypass (CPB) surgery, (PRE), during surgery (SURG), and 48 to 72 h after surgery (POST). Serial blood (n = 16), urine, and SURG tissue samples were collected after intravenous administration of a single 300-mg do...
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One gram of ceftriaxone was given intravenously to 15 patients approximately 2 h before cardiopulmonary bypass surgery. Ceftriaxone levels in plasma (mean +/- standard deviation) were 60.4 +/- 18.8 micrograms/ml (range, 17.0 to 96.0 micrograms/ml) at the beginning of bypass, 44.2 +/- 16.6 micrograms/ml (range, 9.4 to 78.6 micrograms/ml) at the end of bypass, and 19.6 +/- 9.6 micrograms/ml (rang...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2006
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2006.01896.x